Critical Care Trauma Centre. Phenylephrine Neosynephrine. May be titrated by a nurse in Adult Critical Care. Must be administered via central venous access device; in emergency situations may be temporarily infused through a peripheral vasuclar access device until a central venous line can be established. Patient requires placement of an arterial line to monitor BP. Continuous infusions must be administered by infusion device and the pump library must be enabled.
Chapter 30- Adrenergic Agonists My Nursing Test Banks
Pulmcrit - An alternative viewpoint on phenylephrine infusions
Also Visit CVphysiology. Klabunde These receptors are linked to Gq-proteins that activate smooth muscle contraction through the IP 3 signal transduction pathway. These receptors are linked to Gi-proteins , and binding of an alpha-agonist to these receptors decreases intracellular cAMP, which causes smooth muscle contraction. Alpha-agonists constrict both arteries and veins; however, the vasoconstrictor effect is more pronounced in the arterial resistance vessels. Constriction of the resistance vessels small arteries and arterioles increases systemic vascular resistance , whereas constriction of the venous capacitance vessels increases venous pressure.
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Phenylephrine PE causes vasoconstriction through alpha adrenergic receptors. PE-induced vasodilatation has also been reported earlier in pre-constricted vessels. Here we demonstrate in spiral strips of goat arteries that addition of PE can decrease tone even from base-line levels i. Under control conditions, PE caused vasoconstriction, but under conditions where NO levels are higher, as with L-Arginine or sodium nitroprusside, PE decreased vessel tension.